Agmatine shows promise for alleviating neuropathic pain and drug addiction and shows some potential in protecting against strokes and benefitting cognitive health.
Agmatine Sulfate Benefits
- It is considered to be a neurotransmitter and neuromodulator.
- May alleviate pain in pinched nerve
- Supports mitochondrial health (in vitro)
- Promotes antioxidant activity (in vitro)
- May provide mood support
- May promote healing after an injury to nerves (in rodents)
Agmatine is a chemical found in bacteria, plants, and animals, including humans. It is made from the amino acid known as arginine.
Agmatine Sulfate Mode of Action
Agmatine is an amine molecule that is involved in signaling in the human body. It is a bacterial byproduct and is distinguished by the enzyme which synthesizes agmatine from arginine and can be found in fermented foods such as wine, beer, sake, fish, meat products, and coffee.
Agmatine is endogenously produced and is found in the spinal cord and brain and works both as an N-methyl-D-aspartate (NMDAR) antagonist and a nitric oxide synthase (NOS) inhibitor. Research at this time proposes that agmatine is a neurotransmitter-neuromodulator, as it is made, stored, and released in the brain. It is also found in neurons and neural axon terminals. Agmatine interacts with cell-specific receptors and interacts with actions within the central nervous system. However, its role in brain function has not yet been determined because researchers are still studying its biosynthesis and degradation.
Agmatine is expressed in the brain in high concentrations in the inferior section of the hippocampus and cerebral cortex. It crosses the blood-brain barrier. It is interesting to note that administering L-arginine does not increase agmatine concentrations.
Agmatine promotes antioxidant activity by preventing the oxidation of sulfhydryl groups and decreases hydrogen peroxide content.
Agmatine Sulfate Dosage
Agmatine Sulfate provides 500 mg per 1 capsule. Suggested use for adults is 1 capsule by mouth daily, or as directed by your healthcare practitioner.
Agmatine Sulfate Side Effects and Toxicity
Side effects noted in the human clinical study include transient gastrointestinal discomfort at high doses.
A lethal dose was achieved in mice at a dose of 300 mg/kg, 3200 mg/kg in rabbits, and 980 mg/kg in rats.
There is limited data on toxicity in humans, but studies have reported no known side-effects. Short term safety data is available that shows it is safe for up to 21 days. Another study tested the long-term effects of administration up to 115 days and found no adverse effects.