Centrophenoxine is a cholinergic compound which is a derivative of Dimethylaminoethanol (DMAE) and PCA (para-chlorophenoxyacetic acid). As a cholinergic, it increases levels of acetylcholine in the brain. Supports cognitive health in the elderly with age-related decline.
- May increase alertness and support memory
- May increase concentration and focus
- Promotes antioxidant activity
- Supports information recall in elderly animal subjects
- May decrease lipofuscin (pigments related to aging)
- Supports RNA synthesis
Centrophenoxine Mode of Action
Centrophenoxine is an ester (or derivative) of DMAE (Dimethylaminoethanol) that has been modified with the addition of PCA (para-chlorophenoxyacetic acid). It has demonstrated that it increases the amount of choline in the brain, by working through the presynaptic adrenoceptors of cholinergic terminals.
A unique function of Centrophenoxine is the ability to reduce the age-related pigment lipofuscin. Lipofuscins are peroxidized unsaturated fatty acids that are yellow-brown in color and are deposited in aged tissues. The lipofuscins are a combination of transition metals and oxidized lipids which cause a peroxidation reaction that produces radicals. They are mostly found deposited in neurons and cardiac cells and are believed to clog the cellular lysosome, which is responsible for cleaning waste within the cells. The Increases choline in the brain then cannot digest the materials and the lipofuscin substance remains in the cell and becomes a residual body trapped in the cells.
Centrophenoxine provides 250 mg per 1 capsule. Suggested use for adults is 2-4 capsules by mouth daily, or as directed by your healthcare practitioner.
Centrophenoxine Side Effects and Toxicity
Side effects are usually mild and may include headache, nausea, dizziness, gastrointestinal symptoms, and mild stimulant effects.
DO NOT USE if pregnant. Like DMAE, Centrophenoxine can produce birth defects.
Please consult your healthcare practitioner before beginning supplementation, or if you are taking any medications.
Centrophenoxine may interact with blood pressure and it is recommended that those with severely high blood pressure avoid this supplement.