Pyrroloquinoline quinone (PQQ) is a nutrient found in certain fruits, vegetables, tea, and eggs. PQQ supplements appear to improve mitochondrial functioning and improve the brain. As people age, the tiny mitochondria inside cells become increasingly damaged. PQQ is a quinone that could prove to be an important anti-aging supplement.
PQQ (Pyrroloquinoline quinone) Benefits.
- Supports Mitochondrial Function.
- Promotes Cognitive function while aging.
May Improves Sleep Quality.
- Promotes Healthy Cholesterol Levels.
- May reduce oxidative stress.
- Protect the brain from Parkison's Disease, Alzheimer's Disease, and injuries.
- Improve Quality od sleep.
- Lowers inflammation.
- Improved Energy.
- Enhance Memory.
PQQ is a quinone molecule that is found in food sources and mammalian tissue. The highest food sources are fermented soybeans (natto), spinach, green soybeans, field mustard, tofu, green tea, green peppers, kiwi fruits, parsley, and human breast milk.
PQQ acts as a REDOX agent by reducing oxidants and is recycled back into glutathione (the master antioxidant). PQQ can be recycled many thousands of cycles before the end of its function. It was first believed to be a vitamin but is now regarded as a bioactive non-vitamin compound.
Other common REDOX agent supplements include Vitamin C and alpha-lipoic acid. PQQ works by its modification of REDOX proteins in the cell.
PQQ is chemically neuroprotective and regulates a glutamate receptor, NMDA, by inhibiting overexertion of the NMDA signals which can be toxic to the brain. PQQ injected into the brain is accepted as a neuroprotectant, but it is not clear if oral supplementation carries the same benefit.
PQQ protects mitochondria in two ways: first, it maintains mitochondrial mass. Research in vitro has demonstrated that PQQ preserves mitochondria by reducing oxidative stress and inhibiting the death of cells. Secondly, it appears from research in animals that PQQ can stimulate mitochondrial regeneration by stimulating phosphorylation of a cAMP response element-binding protein (CREB) and activating the promotion of a pathway for PGC-1a which is known to control mitochondrial biogenesis.
PQQ supports cognitive function in compromised populations, such as the elderly or those individuals with cognitive impairment, rather than in healthy individuals.
PQQ (Pyrroloquinoline quinone) Dosage
PQQ provides 20 mg per 1 capsule. Suggested use for adults is 1 capsule by mouth daily with a meal.
If you are taking any medications, always consult with your Healthcare Practitioner before beginning any new supplement.
PQQ (Pyrroloquinoline quinone) Side Effects & Toxicity
PQQ is a fairly new supplement and there are few long-term clinical trials detailing the effects on humans.